Patients with growth hormone deficiency associated with intracranial lesions should undergo regular examinations for progression or relapse of the disease.
The New England Journal of Medicine published two editorials hinein 2003 expressing concern about off-Wortmarke uses of HGH and the proliferation of advertisements for "HGH-Releasing" dietary genotropin kaufen supplements, and emphasized that there is no evidence that use of HGH in healthy adults or in geriatric patients is safe and effective – and especially emphasized that risks of long-term HGH treatment are unknown.
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hinein order to predict the safety hinein patients treated with Jintrolong®, we compared the monkey AUC and Cmax at the NOAEL dose (3 mg/kg/week) with the human AUC and Cmax at the clinical dose (0.2 mg/kg/week) rein pediatric GHD patients to generate a safety margin.
Growth hormone fuels childhood growth and helps maintain tissues and organs throughout life. It's produced by the pea-sized pituitary gland — located at the base of the brain. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces.
Jintropin is used to treat growth failure hinein children and adults Weltgesundheitsorganisation lack natural growth hormone. This includes people with short stature due to Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes.
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Representative histopathological images under the control group and all three doses of the Jintrolong® group are shown rein Figure S1.
Jintrolong® is a long-acting PEGylated recombinant human growth hormone (PEG-rhGH) developed for weekly injection in patients with pediatric growth hormone deficiency (PGHD). Although PEG modification of therapeutic proteins is generally considered safe, concerns persist about the potential for adverse vacuolation rein tissues with long-term exposure to PEG-included therapies, particularly in children. We assessed the safety of Jintrolong® hinein cynomolgus monkeys with an examination of vacuolation hinein the brain choroid plexus (CP) and reported long-term clinical safety data obtained from children with PGHD. The toxicity of Jintrolong® was assessed following the 52-week administration with doses at 0.3, 1, or 3 Magnesium/kg/week. The levels of vacuolation of CP in animals were dose-dependent and at least partially reversible after a 104- or 157-week recovery period.
Because hinein the absence of suggestive clinical circumstances there is a significant false-positive error rate rein the response to a single GH stimulation test, we suggest the use of two tests before making this diagnosis."[6]
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